Adam Lange

Emergence of new function through evolutionary divergence of an intrinsically disordered region

This study shows how transient secondary structure in intrinsically disordered regions can generate new molecular functions while preserving ancestral activities in paralogous proteins.

Atomic structure and plasticity of the MthK-CTX complex investigated by cryo-EM, NMR, and MD simulations

The paper investigates the binding of scorpion toxin CTX to the MthK channel using cryo-EM, NMR, and MD simulations to explain toxin affinity and subtype tolerance.

Atomic structure and dynamics of the mechanosensitive channel MscL from E. coli by cryo-EM and solid-state NMR

This study uses cryo-EM and solid-state NMR to determine the structure and dynamics of MscL from E. coli, revealing lipid-protein interactions that drive mechanosensitive gating.

Atomistic Mechanism of Calcium-Mediated Inward Rectification of the MthK Potassium Channel by Solid-State NMR and MD Simulations

This study identifies a calcium-mediated gating mechanism in the MthK potassium channel using solid-state NMR and MD simulations, revealing how Ca2+ blocks outward K+ flow while allowing inward flow.