Michail S. Lionakis

This study shows Candidozyma auris uses transferrin-bound iron for growth and virulence, not heme, and identifies transferrin saturation as a host susceptibility factor.

This study shows that fungal-induced immunosurveillance remodels the oral mucosal barrier via a non-canonical IL-22 receptor complex, enhancing resistance to Candida albicans colonization.

This study investigates the effects of selective JAK inhibition in AIRE-deficient mice, finding that JAK2 inhibition is most effective in reducing IFN-γ-driven autoimmunity.

This study shows hepcidin deficiency increases susceptibility to Candida albicans infection by promoting fungal growth and kidney damage, and suggests hepcidin mimetics as a potential treatment.

This study identifies GM-CSF produced by SPC+ epithelial cells as critical for neutrophil-mediated immunity against Aspergillus fumigatus, enhancing fungal killing and host survival.

The paper identifies a cDC1-CD8/NKT regulatory circuit that limits plasma cell accumulation after injury, which is disrupted by microplastic contamination.

This study uses single-cell transcriptomics to identify immune responses and IL-1Ra-IL-1R evasion strategies in C. auris skin infection.

This study identifies endothelial RhoA activation as a key driver of tumor cell transendothelial migration and metastasis, showing it can be inhibited to reduce metastatic potential.

The paper studies chaotic dynamics in hematopoiesis using mouse data, showing leukocyte fluctuations are chaotic and can transition to oscillations with B cell accumulation.