Author

Younghoon Jang

National Institutes of HealthORCID 0000-0002-5705-4945Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Ji‐Eun LeeiD· 3 shared Kai GeiD· 3 shared Young-Kwon ParkiD· 3 shared Chengyu LiuiD· 2 shared Aaron BrouniD· 1 shared Anna D. SenftiD· 1 shared Chaochen WangiD· 1 shared Danyang WaniD· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMolecular Biology

Ji‐Eun LeeORCID

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3 papers

Recent·Most cited

MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner

Guojia Xie, Ji‐Eun Lee, Anna D. Senft, Young-Kwon Park, Younghoon Jang, Shreeta Chakraborty, Joyce J. Thompson, Kaitlin E. McKernan, Chengyu Liu, Todd S. Macfarlan, Pedro P. Rocha, Weiqun Peng, Kai Ge

This study shows that MLL3/MLL4 methyltransferase activities are essential for early embryonic development and stem cell differentiation, but their role is lineage-selective and not dependent on enhancer activation.

Nature Genetics · Apr 1, 2023Peer-reviewedMolecular Biology

MED1 is a lipogenesis coactivator required for postnatal adipose expansion

Younghoon Jang, Young-Kwon Park, Ji‐Eun Lee, Danyang Wan, Nhien Tran, Oksana Gavrilova, Kai Ge

This study shows MED1 is essential for postnatal adipose expansion and de novo lipogenesis gene induction in mice, but not for adipose development or early adipogenesis.

bioRxiv · Nov 16, 2020Developmental Biology

H3.3K4M destabilizes enhancer epigenomic writers MLL3/4 and impairs adipose tissue development

Younghoon Jang, Aaron Broun, Chaochen Wang, Young-Kwon Park, Lenan Zhuang, Ji‐Eun Lee, Eugene Froimchuk, Chengyu Liu, Kai Ge

This study shows that H3.3K4M destabilizes MLL3/4 proteins, preventing enhancer activation and impairing adipose tissue development.

Nucleic Acids Research · Oct 10, 2018Peer-reviewedMolecular Biology