Astrid D. Desiree Haase

This study generates spermatogonia from human and non-human primate pluripotent stem cells using xenogeneic testes, providing models for male infertility research.

The paper identifies pachytene piRNAs as precise gene regulators during meiosis, showing they target specific mRNAs through near-perfect complementarity.

The paper investigates the dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes, revealing expanded piwil1 genes and divergent piRNA-producing loci.

The paper identifies genomic regions critical for sperm head-tail connection in Drosophila through a deficiency screen combined with RNAseq analysis.

This study investigates how N-terminal phosphorylation and asymmetric transposon ends regulate piggyBac transposition in mammalian cells, revealing mechanisms that inhibit the process.

The paper identifies conserved rules for generating a single major piRNA 3'-end in flies and mice, revealing a hierarchy between length and sequence preferences.

This study uses bulk and single-cell assays to analyze gene expression, histone modifications, and chromatin features in ESCs transitioning to mesoderm lineages, identifying cis-regulatory elements and transcription factors involved in lineage specification.

The paper identifies two classes of piRNAs based on abundance and function in genome defense, showing that abundance determines functional effectiveness.