Hosiana Abewe

Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer

The paper identifies genomic features affecting ERα binding and gene expression in endometrial cancer, finding cell-type-specific transcription factors and distinct predictive features compared to breast cancer.

Estrogen-induced chromatin looping changes identify a subset of functional regulatory elements

The paper identifies estrogen-induced chromatin looping changes in endometrial cancer cells and shows their correlation with transcriptional responses, though not all loops are essential for estrogen regulation.

Cis-regulatory control of transcriptional timing and noise in response to estrogen

This study identifies cis-regulatory elements that control transcriptional timing and noise in response to estrogen using single-cell RNA-seq and machine learning.

Oct1 cooperates with Smad transcription factors to promote mesodermal lineage specification

This study shows that Oct1 works with Smad factors to activate mesodermal genes during differentiation, improving understanding of lineage specification.