The brain-meningeal interface functions as a reservoir and entry site for brain parenchymal macrophages
Deniz Kaymak, Phil T. Williams, Sabrina A. Hogan, Marie‐Françoise Ritz, Giulia Di Bartolomei, Sihan Zhu, Siling Du, Hassan Melhem, Ana C. Delgado, Tala Shekarian, Marta McDaid, Alexandra Gerber, Igor Smirnov, Patrice Zeis, Timo Schenker, , Gregor Hütter
The paper shows that CNS macrophage engraftment depends on TRM self-renewal and niche timing, not prolonged vacancy, and identifies a peripheral BAM-like macrophage population in aged human brains.
bioRxiv · Jul 20, 2026 · PreprintNeuroscience