Gregor Hütter

Progressive neuronal network reorganisation in glioblastoma drives pathological activity in vitro

This study uses an in vitro platform to show that glioblastoma induces progressive reorganisation of neuronal networks, leading to altered network dynamics and reduced computational capacity.

The brain-meningeal interface functions as a reservoir and entry site for brain parenchymal macrophages

The paper shows that CNS macrophage engraftment depends on TRM self-renewal and niche timing, not prolonged vacancy, and identifies a peripheral BAM-like macrophage population in aged human brains.

In vivo screening of TCR-based chimeric antigen receptors for improved anti-tumor functionality

This study screens TCR-based CAR designs to improve anti-tumor efficacy by incorporating CD28 and CD27 costimulatory domains, showing enhanced performance in mouse tumor models.

Bifunctional Phagocytic Synapse Enhancers for Cancer Immunotherapy

This paper introduces PSEs, bifunctional molecules that enhance phagocytosis and block PD-L1, showing improved antitumor responses in animal models.

Biophysical basis for the induction of glioblastoma-like phenotype in astrocytes

The paper shows that nanoroughness induces a glioblastoma-like phenotype in astrocytes through spheroid formation, MMP2 activation, and gene expression changes.