Daniel Shewring

The paper analyzes the topology of fibroblastic reticular cell networks in lymph nodes to predict breast cancer outcomes, finding that denser networks correlate with better or worse survival depending on disease stage and treatment.

This study shows that radiation-induced podoplanin-positive fibroblasts limit CD8+ T-cell access to tumour cells, reducing radiotherapy effectiveness, and that disrupting PDPN signaling enhances tumour control.