Sophie E. Acton

The paper identifies nanovascular conduits formed by reticular fibroblasts that remove toxic proteins like tau and Abeta from the brain in mice and humans.

The paper quantifies ECM's role in lymph node mechanics and shows how ECM stiffness and FRC contractility affect tissue remodelling and expansion.

The paper analyzes the topology of fibroblastic reticular cell networks in lymph nodes to predict breast cancer outcomes, finding that denser networks correlate with better or worse survival depending on disease stage and treatment.

This study shows that radiation-induced podoplanin-positive fibroblasts limit CD8+ T-cell access to tumour cells, reducing radiotherapy effectiveness, and that disrupting PDPN signaling enhances tumour control.