Author

Spyridon Makris

MRC Laboratory for Molecular Cell BiologyORCID 0000-0001-9243-2369Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Sophie E. ActoniD· 2 shared Agnesska C. BenjaminiD· 1 shared Alan A. MelcheriD· 1 shared Amy BurleyiD· 1 shared Amy LlewellyniD· 1 shared Anna Clare WilkinsiD· 1 shared Anna MikolajczakiD· 1 shared Ben O’LearyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiophysics

Sophie E. ActonORCID

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2 papers

Recent·Most cited

The Extracellular Matrix Regulates Tissue Mechanics to Enable Cyclic Lymph Node Remodelling for Sustained Immunity

Veronika Lachina, Pablo Vicente‐Munuera, Amy Llewellyn, Spyridon Makris, Agnesska C. Benjamin, Kalnisha Naidoo, Yanlan Mao, Sophie E. Acton

The paper quantifies ECM's role in lymph node mechanics and shows how ECM stiffness and FRC contractility affect tissue remodelling and expansion.

bioRxiv · Sep 15, 2026 · PreprintBiophysics

Rapid expansion of podoplanin-positive fibroblasts following radiation limits the anti-tumour CD8+ T-cell response to radiotherapy.

Anna Clare Wilkins, Spyridon Makris, Mary J. Green, Steven Hooper, Anna Mikolajczak, Giovanni Giangreco, Srinivas Allanki, Emma L. Nye, Emma Connick, Richard Mitter, Sam Cooper, Emily Durie, Malin Pedersen, Amy Burley, Katie O’Fee, , Erik A. Sahai

This study shows that radiation-induced podoplanin-positive fibroblasts limit CD8+ T-cell access to tumour cells, reducing radiotherapy effectiveness, and that disrupting PDPN signaling enhances tumour control.

bioRxiv · Oct 7, 2025 · PreprintCancer Biology