Author

Mohammed Enamul Hoque

Kent State UniversityORCID 0000-0003-2439-2355Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Hamza BalciiD· 2 shared Mohammad Lutful Kabir· 2 shared Sajad A. ShiekhiD· 2 shared Soumitra BasuiD· 2 shared Janan Alfehaid· 1 shared Sineth G. KodikaraiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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2 shared papersMolecular Biology

Hamza BalciORCID

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2 papers

Recent·Most cited

Molecular BiologyNAR Molecular MedicinePeer-reviewedJan 1, 2025

Combining the CRISPR Activation and Interference Capabilities Using dCas9 and G-Quadruplex Structures

Mohammad Lutful Kabir, Sineth G. Kodikara, Mohammed Enamul Hoque…·Hamza Balci

This study shows that CRISPR-dCas9 targeting G-quadruplex structures in the c-Myc promoter can activate or suppress gene expression, with dual targeting achieving significant reductions in mRNA and protein levels.

1 citation

humanCRISPR screen

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Molecular BiologybioRxivPreprintMar 17, 2024

Stalling of Transcription by Putative G-quadruplex Sequences and CRISPR-dCas9

Mohammed Enamul Hoque, Mohammad Lutful Kabir, Sajad A. Shiekh…·Soumitra Basu

The paper investigates how CRISPR-dCas9 and G-quadruplex sequences affect transcription by studying their impact on RNA polymerase elongation in specific promoter regions.

DOI 10.1101/2024.03.17.585391

experimental assay

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