Janan Alfehaid

Cap-Independent Translation Regulation of VEGF Using CRISPR-dCas13d

This study shows CRISPR-dCas13d can repress VEGF translation by destabilizing its G-quadruplex IRES under hypoxia, without affecting mRNA levels.

Accessibility of Telomeric Overhangs to Stabilizing Small-Molecule Ligands

This study investigates how telomeric overhang architecture affects small-molecule ligand accessibility by analyzing binding stoichiometry and cooperativity in G-quadruplex structures.

Impact of Molecular Crowding on Accessibility of Telomeric Overhangs Forming Multiple G-quadruplexes

This study investigates how molecular crowding affects the accessibility and structure of telomeric overhangs with multiple G-quadruplexes using smFRET and FRET-PAINT.

Combining the CRISPR Activation and Interference Capabilities Using dCas9 and G-Quadruplex Structures

This study shows that CRISPR-dCas9 targeting G-quadruplex structures in the c-Myc promoter can activate or suppress gene expression, with dual targeting achieving significant reductions in mRNA and protein levels.

Reusable Microfluidic Chambers for Single-Molecule Microscopy

This paper demonstrates a method to reset and reuse single-molecule microfluidic chambers using photocleavable biotin and UV light, enabling at least 10 cycles without surface degradation.

Protection of the Telomeric Junction by the Shelterin Complex

This study investigates how the shelterin complex protects the telomeric junction by bridging single- and double-stranded telomeric DNA, enhancing POT1 binding stability and junction protection.