Soumitra Basu

This study shows CRISPR-dCas13d can repress VEGF translation by destabilizing its G-quadruplex IRES under hypoxia, without affecting mRNA levels.

This study shows that CRISPR-dCas9 targeting G-quadruplex structures in the c-Myc promoter can activate or suppress gene expression, with dual targeting achieving significant reductions in mRNA and protein levels.

The paper investigates how CRISPR-dCas9 and G-quadruplex sequences affect transcription by studying their impact on RNA polymerase elongation in specific promoter regions.

The paper links NAT8L mRNA oxidation to reduced NAA levels and neurodegeneration in multiple sclerosis.