Sajad A. Shiekh

This study investigates how telomeric overhang architecture affects small-molecule ligand accessibility by analyzing binding stoichiometry and cooperativity in G-quadruplex structures.

This paper introduces RECON grooves, an electrokinetic platform for controlled capture, retention, and release of nanoscale vesicles with optical trajectory analysis.

This study investigates how molecular crowding affects the accessibility and structure of telomeric overhangs with multiple G-quadruplexes using smFRET and FRET-PAINT.

This study shows that CRISPR-dCas9 targeting G-quadruplex structures in the c-Myc promoter can activate or suppress gene expression, with dual targeting achieving significant reductions in mRNA and protein levels.

This study investigates how the shelterin complex protects the telomeric junction by bridging single- and double-stranded telomeric DNA, enhancing POT1 binding stability and junction protection.

The paper investigates how CRISPR-dCas9 and G-quadruplex sequences affect transcription by studying their impact on RNA polymerase elongation in specific promoter regions.