Marcin Piechota

preSCRIPT filters and annotates prescription data from UK Biobank to derive drug response phenotypes, replicating known PGx associations and identifying novel candidates.

This study shows risperidone alters gene expression in specific brain regions of mice, with 21 of the affected genes linked to schizophrenia.

The paper examines L-DOPA-induced gene expression changes in the forebrain of mice with progressive dopaminergic neuron loss, identifying region-specific effects and novel genes involved in nonmotor PD symptoms.

The paper identifies glucocorticoid receptor-mediated astrocyte reprogramming in depression using post-mortem samples and mouse models.

The paper identifies a long 3' untranslated region in the primary Oprm1 transcript in mice, with additional variants expressed at lower levels.

This paper introduces PharmGScore, a genetic variant burden scoring system for antidepressant response, showing it outperforms existing methods and identifies gene associations with antidepressant toxicity.

The paper constructs an oligogenic risk model for tic disorders using whole-genome sequencing data, revealing a genetic continuum from healthy individuals to severe Gilles de la Tourette syndrome cases.

This study examines how L-DOPA affects gene expression in the frontal cortex of rats with unilateral dopaminergic lesions, identifying bilateral gene expression changes and non-specific drug effects.