Michał Korostyński

preSCRIPT: Large-scale prescription search and annotation engine for pharmacogenomic studies

preSCRIPT filters and annotates prescription data from UK Biobank to derive drug response phenotypes, replicating known PGx associations and identifying novel candidates.

Risperidone regulates the expression of schizophrenia-related genes in the murine forebrain

This study shows risperidone alters gene expression in specific brain regions of mice, with 21 of the affected genes linked to schizophrenia.

Separating the genetics of disease, treatment and treatment response using graphical modeling and large-scale electronic health records.

The paper uses graphical modeling on electronic health records to separate genetic effects on disease, treatment, and treatment response in large-scale biobank data.

L-DOPA induces spatially discrete changes in gene expression in the forebrain of mice with a progressive loss of dopaminergic neurons

The paper examines L-DOPA-induced gene expression changes in the forebrain of mice with progressive dopaminergic neuron loss, identifying region-specific effects and novel genes involved in nonmotor PD symptoms.

Dystrophin Dp71 is essential for the development and function of macrophages

This study shows that Dp71 dystrophin is essential for macrophage development and function, as its absence disrupts migration, phagocytosis, and inflammasome activity in mouse macrophages.

Glucocorticoid receptors mediate reprogramming of astrocytes in depression.

The paper identifies glucocorticoid receptor-mediated astrocyte reprogramming in depression using post-mortem samples and mouse models.

NF-kappaB and JNK pathways mediate metabolic adaptation upon ESCRT-I deficiency

This study shows that ESCRT-I deficiency leads to metabolic reprogramming via NF-kappaB and JNK pathways, causing increased glycolysis and lipid accumulation.

μ-Opioid receptor transcriptional variants in the murine forebrain and spinal cord

The paper identifies a long 3' untranslated region in the primary Oprm1 transcript in mice, with additional variants expressed at lower levels.

PharmGScore scores of compound genetic variant burden for psychiatric treatment optimization

This paper introduces PharmGScore, a genetic variant burden scoring system for antidepressant response, showing it outperforms existing methods and identifies gene associations with antidepressant toxicity.

Astrocytic Foxo1 regulates hippocampal spinogenesis and synaptic plasticity to enhance fear memory

This study identifies Foxo1 as a key regulator of astrocytic calcium signaling in the hippocampus, influencing spinogenesis, synaptic plasticity, and fear memory.

Downregulation of dystrophin expression occurs across diverse tumors, correlates with the age of onset, staging, and reduced survival of patients.

This study shows that dystrophin expression is downregulated in many tumors, linked to advanced stages, older age of onset, and poorer survival.

Oligogenic risk model for Gilles de la Tourette syndrome reveals a genetic continuum of tic disorders

The paper constructs an oligogenic risk model for tic disorders using whole-genome sequencing data, revealing a genetic continuum from healthy individuals to severe Gilles de la Tourette syndrome cases.

Effects of L-DOPA on gene expression in the frontal cortex of rats with unilateral lesion of midbrain dopaminergic neurons

This study examines how L-DOPA affects gene expression in the frontal cortex of rats with unilateral dopaminergic lesions, identifying bilateral gene expression changes and non-specific drug effects.