Jacek Hajto

preSCRIPT: Large-scale prescription search and annotation engine for pharmacogenomic studies

preSCRIPT filters and annotates prescription data from UK Biobank to derive drug response phenotypes, replicating known PGx associations and identifying novel candidates.

Separating the genetics of disease, treatment and treatment response using graphical modeling and large-scale electronic health records.

The paper uses graphical modeling on electronic health records to separate genetic effects on disease, treatment, and treatment response in large-scale biobank data.

L-DOPA induces spatially discrete changes in gene expression in the forebrain of mice with a progressive loss of dopaminergic neurons

The paper examines L-DOPA-induced gene expression changes in the forebrain of mice with progressive dopaminergic neuron loss, identifying region-specific effects and novel genes involved in nonmotor PD symptoms.

Dystrophin Dp71 is essential for the development and function of macrophages

This study shows that Dp71 dystrophin is essential for macrophage development and function, as its absence disrupts migration, phagocytosis, and inflammasome activity in mouse macrophages.

μ-Opioid receptor transcriptional variants in the murine forebrain and spinal cord

The paper identifies a long 3' untranslated region in the primary Oprm1 transcript in mice, with additional variants expressed at lower levels.

PharmGScore scores of compound genetic variant burden for psychiatric treatment optimization

This paper introduces PharmGScore, a genetic variant burden scoring system for antidepressant response, showing it outperforms existing methods and identifies gene associations with antidepressant toxicity.