Author

Nick Lewis

University of WarwickORCID 0000-0003-2513-8914Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:E. coli· 1

Frequent Co-Authors

Catherine E RowlandiD· 2 shared Christopher Gerard DowsoniD· 2 shared Hector NewmaniD· 2 shared Michael J. DawsoniD· 2 shared Michael J. SkynneriD· 2 shared Paul BeswickiD· 2 shared Tazmin T. MartiniD· 2 shared Adrian J. LloydiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Catherine E RowlandORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintMar 10, 2026

Discovery, characterisation and optimisation of bicyclic peptide inhibitors that disarm Staphylococcus aureus a-hemolysin

Jonathan Whiteside, Nick Lewis, L. Diaz Saez…·Catherine E Rowland

The paper identifies and optimizes bicyclic peptide inhibitors of Staphylococcus aureus α-hemolysin, achieving sub-micromolar affinity and demonstrating functional inhibition of toxin activity.

DOI 10.64898/2026.03.09.710508

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistryCommunications BiologyPeer-reviewedMay 28, 2025

Discovery and chemical optimisation of a Potent, Bi-cyclic (Bicycle(R)) Antimicrobial Inhibitor of Escherichia coli PBP3

Catherine E Rowland, Hector Newman, Tazmin T. Martin…·Michael J. Dawson

This study discovers and optimizes bicyclic peptide inhibitors of E. coli PBP3, showing high-affinity binding and broad-spectrum antimicrobial activity.

11 citations

E. coliexperimental assay

𝕏 PostBluesky