Author

Noah Lubben

Van Andel Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:metagenomics· 1

Frequent Co-Authors

Bryan A. KillingeriD· 2 shared Elizabeth EnsinkiD· 2 shared Peipei LiiD· 2 shared Viviane LabrieiD· 2 shared Ali YılmaziD· 1 shared Bin ZhangiD· 1 shared Cheryl E. G. LeynsiD· 1 shared Connor M. WebbiD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Bryan A. KillingerORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology spread

Noah Lubben, Julia K. Brynildsen, Connor M. Webb, Howard Liu Li, Cheryl E. G. Leyns, Lakshmi N. Changolkar, Bin Zhang, Emily S. Meymand, Mia O’Reilly, Zach B. Madaj, Daniella DeWeerd, Matthew J. Fell, Virginia M.‐Y. Lee, Danielle S. Bassett, Michael X. Henderson

This study shows that LRRK2 kinase inhibition reverses tau pathology progression in mice with the G2019S mutation but not in wildtype mice.

Translational Neurodegeneration · Mar 4, 2024Peer-reviewedNeuroscience

Gut microbiome dysbiosis is associated with elevated toxic bile acids in Parkinson's disease

Peipei Li, Bryan A. Killinger, Ian Beddows, Elizabeth Ensink, Ali Yılmaz, Noah Lubben, Jared A. Lamp, Meghan Schilthuis, Irving E. Vega, Markus Britschgi, John Andrew Pospisilik, Patrik Brundin, Lena Brundin, Stewart Francis Graham, Viviane Labrie

This study identifies elevated toxic bile acids in Parkinson's disease patients and links them to gut microbiome dysbiosis and early biliary changes.

bioRxiv · Sep 26, 2020 · PreprintNeuroscience

Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective

Lee L. Marshall, Bryan A. Killinger, Elizabeth Ensink, Peipei Li, Katie X. Li, Wei Cui, Noah Lubben, Matthew J. Weiland, Xinhe Wang, Juozas Gordevičius, Gerhard A. Coetzee, Jiyan Ma, Stefan V. Jovinge, Viviane Labrie

The paper identifies increased TET2 expression as a driver of epigenetic dysregulation in Parkinson’s disease neurons and shows that reducing Tet2 activity is neuroprotective in mice.

Nature Neuroscience · Aug 17, 2020Peer-reviewedNeuroscience