Gerard D. Wright

Exploring the antibiotic-producing capabilities of Canadian High Arctic bacteria

This study screens Arctic bacteria to discover antibacterial compounds, identifying koreenceine A from a Pseudomonas isolate and confirming its antibiotic activity through genetic analysis.

Streptomyces induces unisexual reproduction of a major human fungal pathogen

This study shows that tunicamycin from Streptomyces induces unisexual reproduction in Cryptococcus species through meiotic processes and developmental reprogramming.

The Caenorhabditis elegans bacterial microbiome influences microsporidia infection through nutrient limitation and inhibiting parasite invasion

The paper shows that certain bacteria reduce microsporidia infection in C. elegans by altering host metabolism and producing inhibitory compounds.

Vacidobactin A: An anti-Pseudomonas aeruginosa siderophore

This paper identifies vacidobactin A, a siderophore from Variovorax paradoxus, that inhibits Pseudomonas aeruginosa growth by limiting iron availability and synergizes with thiostrepton.

Butyrolactol A potentiates caspofungin efficacy against resistant fungi via phospholipid flippase inhibition

The paper identifies butyrolactol A as a compound that enhances caspofungin efficacy against resistant fungi by inhibiting phospholipid flippase, thereby improving antifungal treatment.

A ubiquitous Streptomyces biosynthetic megacluster encodes an arsenal of synergistic biotin-targeting antibiotics

The paper identifies a conserved Streptomyces biosynthetic megacluster producing biotin-targeting antibiotics, effective against multidrug-resistant E. coli.

A Saccharomyces boulardii synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation

This paper develops a Saccharomyces boulardii platform for producing and delivering therapeutic nanobodies to treat gastrointestinal inflammation in mice.

CARPDM: cost-effective antibiotic resistome profiling of metagenomic samples using targeted enrichment

CARPDM enables cost-effective antibiotic resistome profiling in metagenomic samples through targeted enrichment and in-house probe synthesis.

The histidine kinase VraS orchestrates the cell-wall stress response in Staphylococcus aureus via its direct interaction with glycopeptides and β-lactams

This study identifies VraS as a direct receptor for vancomycin and ampicillin, revealing its role in activating the cell-wall stress response in Staphylococcus aureus and providing a target for combating antibiotic resistance.

Diversity, functional classification and genotyping of SHV β-lactamases in Klebsiella pneumoniae

This paper reclassifies SHV β-lactamase alleles in K. pneumoniae genomes based on mutations, improving genotype-phenotype understanding and updating the Kleborate tool.

Structural and evolutionary analyses support reclassification of glycopeptide antibiotics as xyclopeptides

The paper reclassifies glycopeptide antibiotics as xyclopeptides based on structural and evolutionary analyses of biosynthetic gene clusters.