Author

Aline Fiebig‐Comyn

Michael G. DeGroote Institute for Infectious Disease ResearchORCID 0009-0009-0786-4331Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Brian K. CoombesiD· 4 shared Gerard D. WrightiD· 2 shared Megan T. ZangaraiD· 2 shared Michael A. CookiD· 2 shared Allison K. GuitoriD· 1 shared Almer M. van der SlootiD· 1 shared Amelia Bing Ya Guo· 1 shared Andrei Bogza· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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4 shared papersMicrobiology

Brian K. CoombesORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Peyer's patches are a niche for antibiotic-driven expansion of Crohn's disease-associated adherent-invasive Escherichia coli

Katarina R Iacobucci, Dominique Tertigas, Aline Fiebig‐Comyn, Megan T. Zangara, Michael Gordon Surette, Brian K. Coombes

This study shows antibiotic treatment increases AIEC burden in Peyers patches, leading to focal inflammation, and identifies specific AIEC traits required for niche colonization and immunopathology.

bioRxiv · May 21, 2026 · PreprintMicrobiology

Butyrolactol A potentiates caspofungin efficacy against resistant fungi via phospholipid flippase inhibition

Xuefei Chen, H. Diessel Duan, Michael J. Hoy, Kalinka K. Koteva, Michaela Spitzer, Allison K. Guitor, Emily Puumala, Aline Fiebig‐Comyn, Guanggan Hu, Bonnie Yiu, Sommer Chou, Zhuyun Bian, Yeseul Choi, Amelia Bing Ya Guo, Wenliang Wang, , Gerard D. Wright

The paper identifies butyrolactol A as a compound that enhances caspofungin efficacy against resistant fungi by inhibiting phospholipid flippase, thereby improving antifungal treatment.

Cell · Dec 31, 2025Peer-reviewedBiochemistry

The Salmonella phage shock protein system is required for defense against host antimicrobial peptides

Marie-Ange Massicotte, Aline Fiebig‐Comyn, Andrei Bogza, Brian K. Coombes

This study identifies the phage shock protein (Psp) system as critical for Salmonella survival within macrophages by mediating resistance to host antimicrobial peptides.

PLoS Pathogens · Sep 9, 2025Peer-reviewedMicrobiology

A Saccharomyces boulardii synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation

Roger Palou, Almer M. van der Sloot, Aline Fiebig‐Comyn, Megan T. Zangara, Naseer Sangwan, María Sánchez‐Osuna, Bushra Ilyas, Haley L. Zubyk, Michael A. Cook, Gerard D. Wright, Brian K. Coombes, Mike Tyers

This paper develops a Saccharomyces boulardii platform for producing and delivering therapeutic nanobodies to treat gastrointestinal inflammation in mice.

bioRxiv · May 15, 2025 · PreprintSynthetic Biology