Elliot J. Jokl

This study shows that PDLIM5 regulates YAP1 localization and fibrogenic gene expression in hepatic stellate cells through mechanical cues.

Spartan identifies spatial domains and variable genes by integrating spatial topology and activation signals in spatial transcriptomics data.

The paper identifies novel fibrosis-associated endothelial cells in early-stage liver disease through integrated analysis of imaging, proteomic, and transcriptomic data.

This study shows that SOX9 is critical for maintaining granuloma structure and ECM barrier formation in schistosomiasis, which protects the liver from damage.

Mantpy is a framework for analyzing the extracellular matrix in spatial proteomics by representing it as spatial graphs and integrating it with cell data for joint analysis.

The paper maps the spatial transcriptional changes in human liver cirrhosis, identifying gene signatures and cell state transitions linked to disease progression.