Courtney Coker

Expanding the therapeutic window of bacteria for cancer therapy

This paper develops a tumor-targeting engineered bacterium that improves therapeutic efficacy and safety in cancer treatment.

Engineered probiotics target granulomas to treat mycobacterial infection

This paper engineers probiotic bacteria to target granulomas and reduce mycobacterial infection in vitro and in vivo.

Engineered bacteria launch and control an oncolytic virus

This paper describes engineered bacteria that deliver a viral genome to initiate oncolytic infection in tumors, demonstrating bacterial control over viral replication.

A programmable probiotic encapsulation system enhances therapeutic delivery in vivo

This paper develops a programmable probiotic encapsulation system using synthetic biology to enhance therapeutic delivery in mice by controlling bacterial immunogenicity and survivability.

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

The paper designs a probiotic platform to deliver checkpoint blockade nanobodies to tumors using a controlled lysing mechanism for therapeutic release.

Multiplexed biosensors for precision bacteria tropism in vivo

This study engineers bacteria to sense and grow in response to specific environmental cues, improving targeted colonization in the gastrointestinal tract.

Programmable bacteria induce durable tumor regression and systemic antitumor immunity

This paper demonstrates that engineered bacteria can deliver immunotherapeutic payloads to induce durable tumor regression and systemic antitumor immunity.