This study validates 5-MOP as a highly selective CSF1R radioligand with nanomolar affinity, enabling accurate detection of drug occupancy and microglial activation.

bioRxiv · May 14, 2026 · PreprintNeuroscience

Serotonin-2B receptor (5-HT2BR) expression and binding in the brain of ageing APPswe/PS1de9 transgenic mice and in human Alzheimer's disease brain tissue

M Anzalone, Sarmad A. Karam, Sanne R. R. Briting, Sussanne Petersen, Majken Borup Thomsen, Anne Marlene Landau, Bente R. Finsen, Athanasios Metaxas

This study examines 5-HT2BR expression and binding in AD mouse models and human tissue, finding age-related changes in mice and higher levels in AD patients.

bioRxiv · May 30, 2024 · PreprintNeuroscience

Tauopathy in the APPswe/PS1ΔE9 mouse model of familial Alzheimer’s disease

Athanasios Metaxas, Camilla Thygesen, Stefan J. Kempf, M Anzalone, Ramanan Vaitheeswaran, Sussanne Petersen, Anne Marlene Landau, Hélène Audrain, Jessica L. Teeling, Sultan Darvesh, David James Brooks, Martin R. Larsen, Bente R. Finsen

This study shows that tau pathology develops spontaneously in APPswe/PS1ΔE9 mice, demonstrating that amyloidosis is necessary and sufficient to drive tauopathy in familial AD models.

Scientific Reports · Oct 31, 2019Peer-reviewedNeuroscience