Dean Bobo

This paper presents the first assembled genome of Aeshna juncea, revealing transposon-driven genome size variation and population bottlenecks in Arctic populations.

The paper quantifies pangenome complexity as information content, finding that free-living bacteria have higher genomic complexity than host-associated species.

Over 400 million variants, 97% below 1% frequency, emerge from deep whole-genome sequencing of 53,831 diverse TOPMed participants; TOPMed haplotypes enable imputation down to ~0.01% frequency.

This paper reports on a pilot genomic screening program in a diverse population, finding higher return rates for hATTR results in African/African American and Hispanic/Latinx participants.

The paper uses exome sequencing and EHR data to find BRCA1/2 pathogenic variants in a diverse biobank population, revealing high prevalence in certain ancestry groups and gaps in knowledge for non-European populations.

The paper analyzes ancient genomic DNA from two cemeteries associated with the Longobards to study social organization and migration patterns in 6th-century Europe.

This study sequenced ancient dog genomes from the Neolithic period in Europe, finding continuity with modern dogs and rejecting a population replacement model and dual origins hypothesis for dog domestication.

The paper quantifies false negative rates in NGS data and introduces a tool to assess them, showing significant FN rates even in high-coverage datasets.

The paper uses genome-wide data to reveal fine-scale population structure in southern Africa, showing that KhoeSan groups' ancestry is shaped by geography and ecology rather than language or subsistence.