Sarah Perry

Distinct input-specific mechanisms enable presynaptic homeostatic plasticity

The paper investigates how two distinct motor inputs contribute to presynaptic homeostatic plasticity (PHP) in Drosophila, showing input-specific mechanisms for stabilizing neuromuscular junction activity.

Tissue-specific knockout in Drosophila neuromuscular system reveals ESCRT's role in formation of synapse-derived extracellular vesicles

The paper develops a CRISPR toolkit for tissue-specific gene knockout in Drosophila motor neurons, muscles, and glial cells, revealing ESCRT's role in NMJ extracellular vesicle formation.

Physiologic and nanoscale distinctions define glutamatergic synapses in tonic vs phasic neurons

The paper identifies physiological and nanoscale differences in glutamatergic synapses between tonic and phasic neurons at the Drosophila neuromuscular junction.

Plasticity of gene expression in the nervous system by exposure to environmental odorants that inhibit HDACs

The paper investigates how exposure to volatile chemicals, like diacetyl, affects gene expression and physiology by inhibiting HDACs in Drosophila and human cells.

Rapid homeostatic modulation of transsynaptic nanocolumn rings

The paper shows that transsynaptic nanocolumn rings rapidly modulate during homeostatic plasticity to stabilize synaptic efficacy.

Excess glutamate release triggers subunit-specific homeostatic receptor scaling

This study shows that excess glutamate release selectively regulates GluR subtypes through competition and Ca2+ signaling in Drosophila.

Contributions of the conserved insect carbon dioxide receptor subunits to odor detection

This study shows that Gr2 and Gr3 subunits are sufficient for CO2 detection in Drosophila, while Gr1 modulates sensitivity and ligand diversity.

Presynaptic depression maintains stable synaptic strength in developmentally arrested Drosophila larvae

The paper investigates how synaptic strength is maintained in Drosophila larvae arrested in development, finding that presynaptic homeostatic depression compensates for excessive synaptic growth.

The sleep gene insomniac ubiquitinates targets at postsynaptic densities and is required for retrograde homeostatic signaling

This study identifies the sleep gene insomniac as essential for retrograde homeostatic signaling by ubiquitinating targets at postsynaptic densities in Drosophila.