Ping Zhu

The paper visualizes chromatin structure and chromatin regulator binding using cryo-ET and subtomogram averaging, revealing nucleosome heterogeneity as a key factor in chromatin flexibility.

The paper develops RFdiffusion to generate protein binders for IDPs/IDRs, achieving nanomolar affinity and functional applications in amylin and IL2RG.

This study uses cryo-electron tomography to reveal the spool-like architecture and infection strategies of the archaeal virus SEV1, showing its flexibility and unique assembly process.

This study uses cryo-ET to analyze the ultrastructure of silkworm, spider, and artificial silk, revealing differences in their fundamental structural units and hierarchical organization.

Noise-Transfer2Clean improves cryo-EM image denoising by modeling and transferring noise characteristics, achieving better signal restoration than existing methods.