Author

Andrew N. Hoofnagle

University of WashingtonORCID 0000-0002-6449-0243Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Deanna L. PlubelliD· 2 shared Michael J. MacCossiD· 2 shared A G MurrayiD· 1 shared Alex KangiD· 1 shared Asim K. BeraiD· 1 shared Brendan MacLeaniD· 1 shared Brian CoventryiD· 1 shared Caixuan LiuiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

Deanna L. PlubellORCID

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Author profile →

3 papers

Recent·Most cited

Serum proteomics reveals distinct phenotypic signatures to IL-6 blockade between two immunotherapies

Catherine M Sniezek, Deanna L. Plubell, Katarina Vlajic, Andy N. Hoofnagle, Christine C Wu, Jane Hoyt Buckner, Devin K. Schweppe, Cate Speake, Michael J. MacCoss

This study compares the effects of two IL-6 inhibitors on serum extracellular vesicles using proteomics, finding distinct protein pathway alterations.

bioRxiv · Mar 30, 2026 · PreprintBiochemistry

Diffusing protein binders to intrinsically disordered proteins

Caixuan Liu, Kejia Wu, Hojun Choi, Hannah L. Han, Xueli Zhang, Joseph L. Watson, Green Ahn, Jason Z. Zhang, Sara Shijo, Lydia L. Good, Charlotte M. Fischer, Asim K. Bera, Alex Kang, Evans Brackenbrough, Brian Coventry, , David A. Baker

The paper develops RFdiffusion to generate protein binders for IDPs/IDRs, achieving nanomolar affinity and functional applications in amylin and IL2RG.

Nature · Jul 30, 2025Peer-reviewedBiochemistry

A framework for quality control in quantitative proteomics

Kristine A. Tsantilas, Gennifer E. Merrihew, Julia E. Robbins, Richard S. Johnson, Jea Park, Deanna L. Plubell, Jesse D. Canterbury, Eric L. Huang, Michael E. Riffle, Vagisha Sharma, Brendan MacLean, Josh Eckels, Christine C. Wu, Michael S. Bereman, Sandra E. Spencer Miko, , Michael J. MacCoss

The paper introduces a framework for quality control in quantitative proteomics, combining internal and external QC measures with tools for data analysis and deposition.

Journal of Proteome Research · Sep 9, 2024Peer-reviewedBiochemistry