Susanne Arnold

The paper investigates the pathogenic mutation m.10191T>C in mitochondrial DNA, showing it leads to reduced complex I function and NADH accumulation, contributing to Leigh syndrome.

This study identifies COA8 as a COX10-binding protein essential for COX10 stability and catalytic activity in human cytochrome c oxidase biogenesis.

The paper identifies a previously overlooked complex between AIFM1 and cytochrome c oxidase using mass spectrometry and proteomic approaches, revealing structural insights and potential roles in OXPHOS and cell death.

CEDAR provides a database for complexome profiling data with standardized formats, a web interface, and tools for analysis and exploration.