Author

Duoduo Zhao

First Affiliated Hospital Zhejiang UniversityORCID 0000-0002-7602-3597Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Jinliang NaniD· 2 shared Xinnuo Yang· 2 shared Xuwen WangiD· 2 shared Yinuo LiniD· 2 shared Zhehua ShaoiD· 2 shared 刘滨晨· 2 shared Anke Heit-Mondrzyk· 1 shared Binben Wang· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMolecular Biology

Jinliang NanORCID

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Author profile →

3 papers

Recent·Most cited

Heat-dependent engagement of a buried mitophagy motif in prohibitin 2

Xinnuo Yang, Yinuo Lin, Zhehua Shao, Xuwen Wang, Duoduo Zhao, 刘滨晨, Jinliang Nan

This study shows that a buried LIR motif in PHB2 responds directly to temperature changes, affecting mitophagy and cardiac injury during heat stroke.

bioRxiv · Oct 28, 2026 · PreprintMolecular Biology

Acetylation of NDUFA13 at K7 Senses OXPHOS Dysfunction to Disrupt Prohibitin Scaffolds and Drive Cristae Remodelling in Heart Failure

Jinliang Nan, Xinnuo Yang, Yinuo Lin, Jian Shen, Hongpeng Chen, Zihan Xu, Jian Ye, Yaping Wang, Danyang Xiong, Changle Ke, Lianlian Zhu, Xiangmin Kong, Zhiwei Zhong, Tanchen Ren, Jun Jiang, , Xiao He

This study identifies NDUFA13-K7 acetylation as a sensor linking OXPHOS dysfunction to cristae remodelling and metabolic changes in heart failure.

bioRxiv · Oct 28, 2026 · PreprintCell Biology

Unbiased functional genetic screens reveal essential RNA modifications in human cancer and drug resistance

Cornelius Pauli, Michael Kienhöfer, Maximilian Felix Blank, Oguzhan Begik, Christian Rohde, Daniel Heid, Fu Yong Xu, Sarah Miriam Naomi Zimmermann, Katharina Weidenauer, Sylvain Delaunay, Nadja Krall, Katrin Trunk, Duoduo Zhao, Fengbiao Zhou, Anke Heit-Mondrzyk, , Michaela Frye

The paper identifies essential RNA modifications in cancer using CRISPR screens and finds that mitochondrial metabolic plasticity influences drug resistance through specific RNA modifications.

bioRxiv · Jul 13, 2024 · PreprintCell Biology