Marianna Tolve

Endocytic adaptor AP-2 maintains Purkinje cell function by balancing cerebellar parallel and climbing fiber synapses

This study shows that AP-2 maintains Purkinje cell function by balancing synaptic inputs from parallel and climbing fibers, preventing degeneration and motor dysfunction.

Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity

This study shows that autophagy regulator ATG5 protects cerebellar Purkinje cells by maintaining glycolytic activity, preventing neurodegeneration through regulation of glucose transporter 2.

AutoGaitA: A versatile quantitative framework for kinematic analyses across species, perturbations and behaviours

AutoGaitA provides a framework for analyzing motor programs across species and behaviors, showing age-related loss of propulsive strength and task-dependent adaptations in mice.

Autophagy regulates neuronal excitability by controlling cAMP/Protein Kinase A signaling

This study shows that autophagy regulates neuronal excitability by controlling cAMP/PKA signaling through the targeting of PKA inhibitory subunits to autophagosomes.

The transcription factor BCL11A defines a distinctive subset of dopamine neurons in the developing and adult midbrain

This study identifies BCL11A as a defining transcription factor for a distinct subset of midbrain dopamine neurons, showing their vulnerability to Parkinson's disease and developmental roles in motor function.