Christina R. Liem

This study identifies structural features of Hmg2 that mediate GGPP-dependent misfolding and regulation, revealing that GGPP binding occurs in the transmembrane domain and loops in the lumenal domain transmit the response.

This paper develops compact CRISPRi sgRNA libraries and optimal effectors to improve knockdown consistency and efficiency in mammalian cells.

This paper develops a method to control gene expression using CRISPR interference and deep learning, revealing gene-specific expression-phenotype relationships.