Author

Benjamin C. Curtis

University of WashingtonORCID 0000-0003-2758-7414Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Ardizon ValdeziD· 2 shared Cailyn H. SpurrelliD· 2 shared Christopher P SaxbyiD· 2 shared James M. RosseriD· 2 shared Michael C. JenseniD· 2 shared Aalton M LandeiD· 1 shared Adam J JohnsoniD· 1 shared Corinne N. SummersiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

Ardizon ValdezORCID

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2 papers

Recent·Most cited

ImmunologyMolecular Therapy — Nucleic AcidsPeer-reviewedSep 29, 2026

Genome-wide CRISPRa screens nominate modulators of CAR T cell survival within distinct tumor cytokine milieus

Benjamin C. Curtis, Cailyn H. Spurrell, Lindsay Flint…·Shannon K. Oda

This paper develops a CRISPRa-based method to identify genes enhancing CAR T cell survival in different tumor environments.

1 citation

humangenetic perturbation / CRISPR

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BioengineeringbioRxivPreprintDec 22, 2023

Rationally designed modular STAT-activating scaffolds enforce cell-intrinsic transcriptional programs augmenting the anti-tumor potency of CAR T cells

Christopher P Saxby, Taylor K Ishida, James M. Rosser…·Michael C. Jensen

This study designs and tests STAT-activating scaffolds to enhance CAR T cell anti-tumor potency, finding that LASI-3 improves function without lymphoproliferative side effects.

DOI 10.1101/2023.12.22.573170

humanbulk RNA-seq

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