Salvador Sierra

This study shows ECE2 regulates KOR internalization and recycling, with implications for developing therapeutics targeting KOR signaling dysregulation.

The paper identifies epigenetic changes in frontal cortex of schizophrenia patients, showing antipsychotic treatment reverses some alterations and amplifies age effects.

This paper identifies a non-enzymatic HDAC inhibitor with anti-tumor and anti-psychedelic effects, showing reduced gene modulation compared to enzymatic inhibitors.

This study identifies a negative regulatory relationship between glucocorticoid receptor signaling and 5-HT2A receptor expression in a mouse model of neurodevelopmental disorder, linking it to synaptic and behavioral deficits.

This study shows that a single dose of the psychedelic DOI causes long-lasting epigenetic and synaptic changes in mice, linked to antidepressant effects and potential risks for psychiatric disorders.