Javier González‐Maeso

This study investigates the molecular mechanisms of serotonergic psychedelics using a neural stem cell model, revealing an integrated 5-HT2A-TrkB signaling network involved in neuroplasticity and metabolic responses.

The paper introduces a low-input microfluidic method to profile lncRNA-chromatin interactions in disease-relevant tissues and cell types, revealing distinct roles of two lncRNAs in schizophrenia.

This study uses quantitative phosphoproteomics to show that hallucinogenic psychedelics induce distinct global phosphorylation patterns compared to non-hallucinogenic analogues, with functional relevance to glycolytic metabolism.

The paper shows that mRNAs for 5-HT2A and mGlu2 receptors associate co-translationally without requiring their encoded proteins, using in vitro and ex vivo experiments.

This study identifies translational dysregulation and MAP2 phosphorylation differences in neural stem cells from offspring exposed to maternal immune activation.

The paper develops a non-radioactive method to measure 5-HT2A receptor activation in the mouse brain via IP1 detection and correlates it with behavioral and pharmacological responses.

The paper identifies epigenetic changes in frontal cortex of schizophrenia patients, showing antipsychotic treatment reverses some alterations and amplifies age effects.

This paper introduces Drop-BS, a droplet-based microfluidic method for single-cell bisulfite sequencing, enabling high-throughput DNA methylome profiling of up to 10,000 cells in 2 days.

This paper identifies a non-enzymatic HDAC inhibitor with anti-tumor and anti-psychedelic effects, showing reduced gene modulation compared to enzymatic inhibitors.

This study identifies a negative regulatory relationship between glucocorticoid receptor signaling and 5-HT2A receptor expression in a mouse model of neurodevelopmental disorder, linking it to synaptic and behavioral deficits.

This study shows that a single dose of the psychedelic DOI causes long-lasting epigenetic and synaptic changes in mice, linked to antidepressant effects and potential risks for psychiatric disorders.