The ALS/FTD-linked protein CHCHD10 associates with the TDP-43 C-terminal domain through a CHCH-helix interface
Karen S. Alarcon-Morales, Sara Pozo, Mauro Aguilera-Toste, Sara Martin-Ramos, Carolina Muguruza, Rodrigo Damián García, Óscar Millet, Ganeko Bernardo‐Seisdedos
This study identifies a CHCH-helix interface between CHCHD10 and TDP-43CTD that modulates their assembly equilibria and aggregation behavior.
bioRxiv · Aug 6, 2026 · PreprintNeuroscience