Chang Lu

The paper introduces a low-input microfluidic method to profile lncRNA-chromatin interactions in disease-relevant tissues and cell types, revealing distinct roles of two lncRNAs in schizophrenia.

The paper integrates epigenomic and transcriptomic data from lung tumors and non-neoplastic tissues to identify cancer-related signaling networks and regulatory changes.

The paper identifies epigenetic changes in frontal cortex of schizophrenia patients, showing antipsychotic treatment reverses some alterations and amplifies age effects.

This paper introduces Drop-BS, a droplet-based microfluidic method for single-cell bisulfite sequencing, enabling high-throughput DNA methylome profiling of up to 10,000 cells in 2 days.

This paper introduces a method to map spatial epigenomic variations in brain tissue at a centimeter scale, revealing dynamic changes in specific brain regions due to seizures.

The paper identifies cell-type-specific epigenomic differences in pre-cancerous breast tissues of BRCA1 mutation carriers compared to non-carriers.

The paper introduces native MOWChIP-seq, a low-input ChIP-seq method, and applies it to study protein binding differences between mouse brain regions.

This study shows that a single dose of the psychedelic DOI causes long-lasting epigenetic and synaptic changes in mice, linked to antidepressant effects and potential risks for psychiatric disorders.