Mikhail Metelev

16S rRNA Modifications Are Dispensable for Viability but Collectively Optimize Ribosome Biogenesis and Translation Initiation in Escherichia coli

This study shows that 16S rRNA modifications are not essential for E. coli viability but improve ribosome biogenesis and translation initiation efficiency.

Ribosome collisions trigger tmRNA-mediated rescue through mRNA disengagement

The paper shows that HrpA-dependent ribosome collision processing recruits tmRNA and Hsp15 to resolve stalled ribosomes in E. coli under antibiotic treatment.

A complex between IF2 and NusA links transcription and translation

This study uses single-molecule tracking in E. coli to show that the longer IF2 isoform interacts with NusA, linking transcription and translation initiation and affecting growth adaptation.

Dynamic binding of the bacterial chaperone Trigger factor to translating ribosomes

This study uses single-particle tracking to show that Trigger factor binds to translating ribosomes in E. coli with two distinct modes and competes with SRP for RNC binding.

Direct measurements of mRNA translation kinetics in living cells

This study directly measures mRNA translation kinetics in living cells using a live-cell ribosome-labeling method and single-molecule tracking.

Phazolicin - a Novel Thiazole/Oxazole-Modified Peptide Inhibiting the Bacterial Ribosome in a Species-Specific Way.

The paper discovers a new LAP antibiotic, phazolicin, which inhibits bacterial ribosomes in a species-specific manner by blocking the exit tunnel.