Author

Clare C. Blackburn

MRC Centre for Regenerative MedicineORCID 0000-0002-6326-640XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:organoid / primary culture· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Paul Rouse· 3 shared Matthias P. LütolfiD· 2 shared Tania HübscheriD· 2 shared Alison FarleyiD· 1 shared Anastasia I. KousaiD· 1 shared Andrea BaconiD· 1 shared Andrea CorsinottiiD· 1 shared Chengrui An· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersDevelopmental Biology

Paul Rouse

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3 papers

Recent·Most cited

Watch-breaker: establishment of a microwell array-based miniaturized thymic organoid model suitable for high throughput applications.

Viktoria Major, Sam Palmer, Paul Rouse, Jan Morys, Timothy Henderson, Tania Hübscher, Joanna Sweetman, Andrea Bacon, Chengrui An, Guiyun Qiu, Yu Wang, Andrea Corsinotti, Justyna Cholewa-Waclaw, Stephen Jonathan Chapman, Matthias P. Lütolf, , Clare C. Blackburn

The paper introduces a microwell array-based thymic organoid model that supports T-cell development and is suitable for high-throughput analysis.

Cell Reports · Apr 15, 2025Peer-reviewedImmunology

Thymic epithelial organoids mediate T cell development

Tania Hübscher, Luis Francisco Lorenzo‐Martín, Thomas Barthlott, Lucie Tillard, J Langer, Paul Rouse, Clare C. Blackburn, Georg A. Holländer, Matthias P. Lütolf

This study establishes thymic epithelial organoids that mimic in vivo thymus function and support T cell development in vitro.

Development · Jul 22, 2024Peer-reviewedDevelopmental Biology

Canonical NOTCH signaling controls the early progenitor state and emergence of the medullary epithelial lineage in fetal thymus development.

Dong Liu, Anastasia I. Kousa, Kathy E. O’Neill, Paul Rouse, Martyna C. Popis, Alison Farley, Simon R. Tomlinson, Svetlana Ulyanchenko, François Guillemot, Philip Allan Seymour, Mette Christine Jørgensen, Palle Serup, Ute Koch, Freddy Radtke, Clare C. Blackburn

This study shows NOTCH signaling regulates early thymic epithelial progenitor cells and mTEC lineage emergence during fetal thymus development.

Development · Jan 1, 2020Peer-reviewedDevelopmental Biology