Author

Alison K. Francois

University of VirginiaORCID 0000-0003-2854-0546Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 3 Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Anna Ruth CliffeiD· 3 shared Chris BoutelliD· 3 shared Sara Anna DochnaliD· 2 shared Abigail L. Whitford· 1 shared Abigail WhitfordiD· 1 shared Ali Rohani· 1 shared Anna Lewis· 1 shared Chandra Shekhar MisraiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMicrobiology

Anna Ruth CliffeORCID

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintNov 23, 2025

Histone H2A Ubiquitination Mediates the Establishment of Reactivation-Competent HSV-1 Latent Infection

James Boehlke, Sara Anna Dochnal, Chandra Shekhar Misra…·Anna Ruth Cliffe

This study shows that H2AK119ub1, deposited by PRC1, is critical for HSV-1 reactivation from latency, while H3K27me3 is not.

DOI 10.1101/2025.11.23.690028

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MicrobiologybioRxivPreprintJan 28, 2025

Interferon Dependent Immune Memory during HSV-1 Neuronal Latency Results in Increased H3K9me3 and Restriction of Reactivation by ATRX

Abigail L. Whitford, Gaelle E Auguste, Alison K. Francois…·Anna Ruth Cliffe

This study shows that interferon-induced H3K9me3 and ATRX restrict HSV-1 reactivation by maintaining epigenetic memory during neuronal latency.

1 citation

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MicrobiologymBioPeer-reviewedFeb 27, 2024

Single-genome analysis reveals heterogeneous association of the Herpes Simplex Virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts

Alison K. Francois, Ali Rohani, M. S. Loftus…·Anna Ruth Cliffe

This study investigates the association of HSV-1 genomes with H3K27me2 and PHF20L1 in fibroblasts, finding that H3K27me2 is linked to genome silencing and that this association is influenced by demethylase activity and transcriptional state.

16 citationstop 4%

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