Author

Theres Friesacher

University of ViennaORCID 0000-0001-5632-3472Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Assay:electrophysiology· 2 Approach:experimental assay· 2 Assay:electronic health records· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Anna Stary‐WeinzingeriD· 3 shared Nathan DascaliD· 3 shared Boris ShalomoviD· 2 shared Daniel YakubovichiD· 2 shared Haritha P. ReddyiD· 2 shared CARMEN W. DESSAUERiD· 1 shared Debi Ranjan TripathyiD· 1 shared Enno KlußmanniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersPharmacology & Toxicology

Anna Stary‐WeinzingerORCID

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3 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintJul 31, 2026

Structural and Functional Characterization of the KCNJ6 G154C Variant Reveals Severe GIRK2 Channel Gain-of-Function and Opportunities for Drug Repurposing

Michael A. Netzer, Ilya Steshin, Theres Friesacher…·Anna Stary‐Weinzinger

The paper characterizes a KCNJ6 G154C variant, revealing its severe gain-of-function in GIRK2 channels and identifies drug candidates for treatment.

DOI 10.64898/2026.07.28.741201

humanelectronic health records

𝕏 PostBluesky

PhysiologyNature CommunicationsPeer-reviewedNov 24, 2025

Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels

Reem Handklo‐Jamal, Tal Keren Raifman, Boris Shalomov…·Nathan Dascal

The paper shows Gβγ interacts with GIRK2 and GIRK1/2 channels with affinities in the microM range, with GIRK1/2 having higher apparent affinity due to a unique Gβγ docking site.

DOI 10.1038/s41467-025-66730-8

Xenopuselectrophysiology

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Pharmacology & ToxicologyBritish Journal of PharmacologyPeer-reviewedJan 15, 2025

Ethosuximide: subunit- and Gβγ-dependent blocker and reporter of allosteric changes in GIRK channels

Boris Shalomov, Theres Friesacher, Daniel Yakubovich…·Nathan Dascal

This study identifies ethosuximide as a subunit-selective, Gβγ-dependent blocker of GIRK channels, revealing its mechanism of action and potential as a therapeutic tool.

6 citations

mouseelectrophysiology

𝕏 PostBluesky