Anastasios E. Damdimopoulos

The paper uses multimodal single-cell profiling to show how puberty and chemotherapy affect pediatric ovarian tissue, identifying vulnerabilities and a potential biomarker.

This study shows that TORC1 modulates cohesin functions in chromosome segregation and gene expression, linking environmental changes to chromosome stability.

This study examines how human ovarian cortical and medullary cells respond to acute X-ray exposure, finding transcriptomic shifts and impaired cell-cell adhesion.

This study shows that glioma-induced DNMT3A reduction in microglia leads to DNA demethylation and an anti-tumoral phenotype, suggesting DNMT3A as a therapeutic target for glioblastoma.

This study develops and characterizes 3D models of human ovarian primary cells using Biosilk scaffolds, showing they maintain key cell types and form a hypoxic core.

This study shows that GDNF regulates serotonin system development and adult function, with excess GDNF linked to neuropsychiatric disorders.

This study identifies gender-specific microbial dysbiosis in pancreatic cancer patients using microbiome data from 191 samples, revealing sex-related differences in bacterial composition and abundance.

The paper identifies a conserved DNA motif bound by PLAG1 that regulates zygotic genome activation in mice and humans, affecting early embryo development.