Ahmed M. Osman

Glioma-induced DNMT3A-dependent reduction of DNA methylation in microglia promotes a transient anti-tumoral phenotype.

This study shows that glioma-induced DNMT3A reduction in microglia leads to DNA demethylation and an anti-tumoral phenotype, suggesting DNMT3A as a therapeutic target for glioblastoma.

Autocrine CXCL1-CXCR2 Signaling Mediates Leptomeningeal Resistance to Radiation Therapy

The paper identifies CXCL1-CXCR2 signaling as a mediator of leptomeningeal metastasis resistance to radiation therapy and presents it as a potential therapeutic target.

Microglia Adopt Temporally Specific States after Irradiation, Correlating with Neuronal Asynchrony

This study tracks microglial state changes and neuronal asynchrony after irradiation in mice, showing delayed microglial responses and two phases of neuronal dysfunction.

Microglial phagocytosis dysfunction during stroke is prevented by rapamycin

This study shows that microglial phagocytosis dysfunction during stroke is prevented by rapamycin, highlighting its potential as a therapeutic target.

Arg1+ microglia are critical for shaping cognition in female mice

This study identifies Arg1+ microglia as a distinct subtype in female mice, showing their role in cognitive function through dendritic spine maturation and behavior.