Leah Flury Wetherill

This paper conducts a multi-ancestry GWAS of stimulant use disorder, identifies 19 genome-wide significant loci, and finds genetic correlations with other psychiatric and substance use disorders.

The paper identifies Bmp signaling pathway mutations as ethanol-sensitive contributors to jaw malformations in zebrafish and humans.

This study performs a multi-ancestral GWAS of DSM-defined nicotine dependence, finding genetic correlations with other substance use disorders and health traits, and identifying a strong general addiction liability factor.

The paper compares genome-wide data from opioid use and dependence cases to identify genetic associations and differences between exposure and dependence.

This study uses polygenic risk scores to predict substance use disorders in two samples, finding increased risk with higher scores but limited clinical utility.

The paper analyzes rare coding variants in smoking and drinking behavior using exome chip data, finding that they contribute to phenotypic variation but require larger samples for individual variant associations.

This study conducts a trans-ancestral GWAS of alcohol dependence, identifying genetic variants and correlations with psychiatric disorders.