Martin Sauvageau

LncRNA-mediated organization of oncogenic chromatin state is a targetable vulnerability in leukemia

This study identifies PAN3-AS1 as an oncogenic lncRNA in AML, shows its role in chromatin organization, and demonstrates RNA-targeting LNP therapy to reduce leukemia burden.

The lncRNA FENDRR fine-tunes FOXF1 protein levels through a negative feedback loop governing human embryonic lung fibroblast-to-myofibroblast transition

The paper identifies a negative feedback loop between lncRNA FENDRR and FOXF1 that regulates protein levels during fibroblast-to-myofibroblast transition in lung development.

ECSFinder: Optimized prediction of evolutionarily conserved RNA secondary structures from genome sequences

ECSFinder improves prediction of evolutionarily conserved RNA structures by combining machine learning with thermodynamic and covariation features from existing tools.

The Tug1 Locus is Essential for Male Fertility

The paper identifies Tug1 as essential for male fertility, showing it has three distinct regulatory activities: a cis DNA repressor, a trans-acting lncRNA, and a conserved peptide affecting mitochondrial function.