Cell BiologybioRxivPreprint
Non-DNA-damaging DNA-PK activation improving hearing and prolonging life due to NAD+ and SIRT upregulation
Yohei Honkura, Takehiro Suzuki, Ryota Kujirai…·Takaaki Abe
This paper shows that MA-5 improves hearing loss and extends lifespan in mice by increasing NAD+ and SIRT1 through DNA-PK activation and mitochondrial function.
DOI 10.1101/2025.04.18.649305