Joseph Sugie

This study identifies chlorotonils as potent anti-Mtb agents and shows resistance is mediated by MmpR5-MmpL5.

The paper identifies thienopyrimidine amides as MmpL3 inhibitors in M. tuberculosis, showing loss of potency in MmpL3 mutants and cell wall stress responses.

The paper shows that MdfA and ClpCP protease regulate metabolic differentiation in Bacillus subtilis sporulation by depleting metabolic enzymes in the forespore.

The paper investigates an arylsulphonamide's mechanism against Mycobacterium tuberculosis, finding it targets cell wall biosynthesis via MmpL3.

The paper uses machine learning to analyze Pseudomonas aeruginosa transcriptomes and identifies gene sets regulated by known transcriptional factors, revealing insights into biosynthetic clusters and metabolic regulation.