Henry H. Le

This study identifies Survivin as a critical KRAS signaling partner that promotes glycolytic activity in PDAC cells by forming microtubule-based complexes with glycolytic enzymes.

The paper identifies gut microbial interactions with omega-3 fatty acids that produce bioactive metabolites present in infant gut metabolomes.

This paper introduces TAMOHA, a biochemical probe that enables comprehensive profiling of electrophilic metabolites, revealing thousands of previously uncharacterized species in E. coli, C. elegans, and mouse.

The paper identifies four O-acetyltransferase genes in C. elegans essential for synthesizing volatile sex pheromones and reveals their dual role in producing both volatile and non-volatile pheromone components.

This study shows that gut bacteria producing sphingolipids transfer these lipids to the skin, altering skin barrier function and gene expression.