Mallory E. Filipp

This study uses machine learning to identify Treg-mediated mechanisms by which nMSCs and their secretome improve diastolic function in HFpEF.

The paper identifies age-specific secretome differences in macrophages under hypoxia and LPS, showing neonatal macrophages have anti-inflammatory, regenerative properties dependent on HIF-1, while adult macrophages show pro-inflammatory, glycolytic responses.