Alessandro Esposito

This study identifies how different KRAS G12 alleles alter glutamine metabolism and nitrogen recycling through FOXO1 regulation in colorectal cancer cells, revealing potential therapeutic targets.

This study uses multiplexed biochemical imaging to reveal caspase activation patterns that determine single-cell fate in response to cisplatin, showing non-genetic heterogeneity in cell death mechanisms.

The paper shows that transient DNA damage with checkpoint non-fidelity leads to varied lineage fitness outcomes in descendant cells, promoting persistence in mutagenic environments.